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Preventative Effect of Zingiber Officinale on Insulin Resistance in a High-Fat, High-Carbohydrate Diet-Fed Rat Model and its Mechanism of Action

Could ginger be the next Diabetes and Obesity treatment?

This study looks at the effects if gingerol, a constituent of ginger, on insulin sensitivity an the results greater muscle uptake of glucose. Very exciting. Ginger continues to be my favorite herbal supplement. - Carl

Abstract: Insulin resistance is a core component of metabolic syndrome and usually precedes the development of type 2 diabetes mellitus. We have examined the preventative effect of an ethanol extract of ginger (Zingiber officinale, Zingiberaceae) on insulin resistance in a high-fat, high-carbohydrate (HFHC) diet-fed rat model of metabolic syndrome. The HFHC control rats displayed severe insulin resistance, whilst rats treated with ginger extract (200 mg/kg) during HFHC diet feeding showed a significant improvement of insulin sensitivity using the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) after 10 weeks (P < 0.01). An in vitro mechanistic study showed that (S)-[6]-gingerol, the major pungent phenolic principle in ginger, dose-dependently (from 50 to150 μM) increased AMPK α-subunit phosphorylation in L6 skeletal muscle cells. This was accompanied by a time-dependent marked increment of PGC-1α mRNA expression and mitochondrial content in L6 skeletal muscle cells. These results suggest that the protection from HFHC diet-induced insulin resistance by ginger is likely associated with the increased capacity of energy metabolism by its major active component (S)-[6]-gingerol. This article is protected by copyright. All rights reserved.

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