Fresh pomegranate juice ameliorates insulin resistance, enhances beta-cell function, and decreases fasting serum glucose in type 2 diabetic patients

Abstract: Although the effects of pomegranate juice (PJ) on type 2 diabetic (T2D) conditions have been reported a clinical study focusing on the short-term effects on different diabetic variables is still needed. We hypothesized that PJ consumption by T2D patients could reduce their insulin-resistant state and decrease their FSG levels, three hrs after juice ingestion. This study demonstrated the direct effect of fresh PJ on fasting serum glucose (FSG) and insulin levels in T2D patients. Blood samples from 85 participants with type 2 diabetes were collected after a 12-hr fast, then one and three hrs after administration of 1.5 mL of PJ, per kg body weight. Serum glucose was measured based on standard methods using the BS-200 Chemistry-Analyzer. Commercially available immunoassay kits were used to measure human insulin. Generally, the results demonstrated decreased FSG, increased β-cell function, and decreased insulin resistance among T2D participants, three hrs after PJ administration (P < 0.05). This hypoglycemic response depended on initial FSG levels, as participants with lower FSG levels (7.1- 8.7 mmol/L) demonstrated a greater hypoglycemic response (P < 0.05) compared with those that had higher FSG levels (8.8-15.8 mmol/L). The effect of PJ was also not affected by the gender of the patient and was less potent in elderly patients. In conclusion, this work offers some encouragement for T2D patients regarding PJ consumption as an additional contribution to control glucose levels.


Alex’s Notes: Diabetic? Have some pomegranate juice. That’s the bottom line of this study, which recruited 85 middle-aged type-2 diabetic patients and 50 healthy controls to drink 1.5mL of pomegranate juice per kilogram of bodyweight after a 12 hour fast. The juice was sourced from hand-picked pomegranates in North Jordan that had their seeds squeezed. Unfortunately, the authors don’t report how many seeds are necessary to get adequate juice (probably a lot), but it does extend the results to the seeds as well if you prefer to eat them.

So what happened? Well, 3 hours after drinking the juice, the diabetics has significantly lower fasting blood glucose levels then before consuming the juice. This wasn’t the case in healthy people by the way. Insulin and HOMA-IR was also lower at the 3 hour time-point, and beta-cell function showed improvement.

So there you go, pomegranate seeds and the juice made from them improve fasting glucose and insulin in type-2 diabetics but not healthy persons. And this only applies to you if you are one of those “juicing” persons that foolishly start your morning with a giant sugary drink. Seriously, if you are diabetic you shouldn’t be juicing, but you should eat some pomegranate seeds. So have them with your egg omelet.


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