Atrk
Menu
AAEFX Carbs Users Guide Free Download

Follistatin promotes adipocyte differentiation, browning, and energy metabolism.

Braga M1Reddy STVergnes LPervin SGrijalva VStout DDavid JLi XTomasian VReid CBNorris KCDevaskar SUReue KSingh R.
1Division of Endocrinology and Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059; and.

Journal

J Lipid Res. 2014 Mar;55(3):375-84. doi: 10.1194/jlr.M039719. Epub 2014 Jan 17.

Affiliation

Abstract

Follistatin (Fst) functions to bind and neutralize the activity of members of the transforming growth factor-β superfamily. Fst has a well-established role in skeletal muscle, but we detected significant Fst expression levels in interscapular brown and subcutaneous white adipose tissue, and further investigated its role in adipocyte biology. Fst expression was induced during adipogenic differentiation of mouse brown preadipocytes and mouse embryonic fibroblasts (MEFs) as well as in cold-induced brown adipose tissue from mice. In differentiated MEFs from Fst KO mice, the induction of brown adipocyte proteins including uncoupling protein 1, PR domain containing 16, and PPAR gamma coactivator-1α was attenuated, but could be rescued by treatment with recombinant FST. Furthermore, Fst enhanced thermogenic gene expression in differentiated mouse brown adipocytes and MEF cultures from both WT and Fst KO groups, suggesting that Fst produced by adipocytes may act in a paracrine manner. Our microarray gene expression profiling of WT and Fst KO MEFs during adipogenic differentiation identified several genes implicated in lipid and energy metabolism that were significantly downregulated in Fst KO MEFs. Furthermore, Fst treatment significantly increases cellular respiration in Fst-deficient cells. Our results implicate a novel role of Fst in the induction of brown adipocyte character and regulation of energy metabolism.

 
 

Network Affiliates

Internet-Radio.com
SHOUTcast.com
TrulyHuge.com
FitnessLinkPros.com
WorldFitness.org
CriticalBench.com
LiftForLife.com
LiveLongerLiveStronger.co.uk

Quick Links I

Our Location

SUPER HUMAN RADIO
2908 Brownsboro Rd
Suite 103
Louisville, KY 40206
(502) 690-2200

SHR Newsletter

Subscribe to our FREE newsletter
to receive the latest updates in your inbox!
SHR Newsletter