Hereditary high blood cholesterol leads to premature heart disease. It is overlooked and untreated virtually worldwide – including in Europe. This is a major problem as the disease is dangerous for health. However, this disease is easy to diagnose and treat, according to the conclusion of a consensus report from the European Atherosclerosis Society. The report was recently published in the recognised medical journal European Heart Journal.
A new consensus report documents massive underdiagnosis and undertreatment of hereditary high blood cholesterol – so-called familial hypercholesterolaemia – in practically all 200 countries in the world, the only exceptions being the Netherlands and Norway.
"In most countries, the number of people with familial hypercholesterolaemia is unknown. This means that the condition is not detected until the person develops heart disease or dies suddenly far too young. Considering how easily the disease can be prevented, this situation is an admission of failure from a health perspective," says Børge Nordestgaard, Clinical Professor at theFaculty of Health and Medical Sciences, University of Copenhagen, and Chief Physician at Copenhagen University Hospital. He is the leading author of the new consensus report, which has been published in the European Heart Journal.
"In the general population, between 1 in 200 and 1 in 500 people inherit the disease familial hypercholesterolaemia, making the disease the most frequent hereditary and fatal disease. However, statins, which are safe and inexpensive treatments, can lower cholesterol levels. For these persons with a greatly increased risk of developing serious heart disease, the few side effects associated with statins are negligible," says Børge Nordestgaard.
Between 14 and 34 million people worldwide are estimated to suffer from familial hypercholesterolaemia. In Europe, the number is between 1.8 and 4.5 million and, in Denmark, between 11,000 and 28,000. These figures are based on the large Copenhagen General Population Study.
"In the Netherlands and Norway, most people suffering from familial hypercholesterolaemia have been identified, and are offered cholesterol-lowering treatment with statins. In Denmark, only an estimated 500 persons with familial hypercholesterolaemia have been identified and undergone sufficient treatment," says Børge Nordestgaard.
Easy to diagnose
Familial hypercholesterolaemia is easy to diagnose; it only requires a blood cholesterol test and a family history of early-onset heart disease. Cholesterol levels above 8 mmol/L in adults and above 6 mmol/L in children are a strong indication of the condition, and the diagnosis can be confirmed by a gene test.
"It is surprising and sad that even rich countries with highly developed health systems fail to help these people. It is not a question of economic resources, as the disease is easy to diagnose and inexpensive to treat," says Professor John Chapman. He is one of the co-authors of the report and Professor at the Pitié-Salpêtrière university hospital in Paris.
Coordinated national effort required
According to Børge Nordestgaard, a coordinated national effort is required, with clinics at all major hospitals in most countries, similar to the existing diabetes clinics.
"It would also improve the registration of familial hypercholesterolaemia and the families affected if the WHO decided to assign the disease its own diagnostic code as is the case with diabetes," Børge Nordestgaard concludes.
Professor Børge Nordestgaard
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The European Atherosclerosis Society Consensus Panel, comprised of 28 internationally renowned experts in atherosclerosis and cardiovascular disease, convened twice to consider the current evidence-base for familial hypercholesterolaemia. The Panel is co-chaired by Professor John Chapman, Pitié-Salpetriere University Hospital, Paris, France and Professor Henry Ginsberg, Columbia University, New York, USA.