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Alex's Amusement 3/18/14

Critical Thinking Corner

A new drug called tenapanor prevents sodium uptake in the intestines by blocking the activity of the NHE3 membrane transporter. Instead, the sodium moves on through to be excreted in feces. In rats, a combination of tenapanor and the popular antihypertensive drug enalapril was more effective at lowering albumin in the urine (a marker of kidney disease), and blood pressure than either drug alone.

Another drug to solve a simple dietary problem; really? Before I mini-rant, I want to point out that YES, this drug could help patients with kidney disease, diabetes and other conditions where damage to the kidney’s affect their ability to eliminate excess salt. The only pharmacologic approach currently available to help control sodium are diuretics, which become less effective if a patient is non-compliant and continues to eat a high-sodium diet. But that is the problem RIGHT THERE, continues to eat a high-sodium diet…

We already know from SuppVersity that salt intake is not correlated with the magnitude of diseases that the mainstream media would have you believe UNLESS you are already fat and sick (see picture below that I stole off Adel’s Facebook). So it seems that rather than to stop eating the sodium ridden processed chips and dip that is causing more problems than just sodium imbalance, the people will take a drug and continue to munch in ignorant bliss. But it’s okay because their physician said so.

What will be interesting to see (assuming someone actually looks into it, which probably won’t happen) is how this affects the microbiota of the individuals. Granted, the fat and sick already have messed up bacteria inside them so the effect may not be as severe (assuming its negative), but since the excess sodium is excreted in feces rather than urine like normal, I can’t help but wonder how the bacteria will respond.

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"Intestinal Inhibition of the Na+/H+ Exchanger 3 Prevents Cardiorenal Damage in Rats and Inhibits Na+ Uptake in Humans," by A.G. Spencer; E.D. Labonte; D.P. Rosenbaum; C.W. Carreras; M.R. Leadbetter; K. Kozuka; J. Kohler; S. Koo-McCoy; L. He; N. Bell; J. Tabora; M. Navre; J.W. Jacobs; D. Charmot at Ardelyx, Inc. in Fremont, CA; C.F. Plato; K.M. Joly at Plato BioPharma, Inc. in Westminster, CO.

Also,

Someone posted on Facebook, “For years I hadn't slept through a whole night without waking, and I was in the habit of having some juice or a little thyroid to help me go back to sleep. The first time I had several grams of gelatin just before bedtime, I slept without interruption for about 9 hours.”

This sparked my interest and my first thought was that it was a placebo effect that occurred because the person was reading about gelatin and all the claimed benefits, and thus expected it to help. However, I thought what is special about collagen? It is just protein. But what type? Collagen and ligaments are primarily glycine with some proline. Well proline is useless for sleep, but glycine actually shows some potential.

Glycine may be necessary for proper REM sleep, and experimental evidences supports the notion that glycine improves sleep quality in a subjective and objective manner and has no serious adverse effects. This other study found that oral administration of glycine to rats increased serotonin production, which is known to be the "feel-good" hormone and help in sleep quality as well. The human equivalent dosage would be 0.3 g/kg bodyweight, or about 25 grams of glycine for a 150 lb human. Going back to the first study cited, there is 25 grams of glycine per 100g of collagen. So one would need to consume 3.5 oz of collagen.

Anyways, interesting to follow the science, for what it's worth... I mean anecdotal evidence can only get you so far.

Around the Web

Milk and cheese consumption result in attenuated increases in LDL-cholesterol compared to a control diet similar in fat content but dairy free.

Mom’s fat intake influences her breast milk. Better stay away from them industrial oils and eat some salmon instead.

Nice giant review on milk, dairy products, and their functional effects in humans.

I may not be a kid (or have any), but this infographic on how to raise the happiest kids is insightful and based in science.

Dropped your food? It’s okay, the five-second rule has been validated.

Caffeine is pretty cool. I watched the image under #4 like five times. Have you ever seen that before???

SuppVersity Post of the Week

More Than -2kg Body Fat in 4 Days? Manic Exercise and a 4-Day x 5,000kcal Energy Deficit on Whey or Sucrose Based Starvation Diet Yield Astonishingly Long-Lasting Fat Loss

If you ever needed a reason to walk for eight hours daily and eat virtually nothing, this is it. A four-day diet to lose nearly 4 kg of weight (of which 75% was fat-mass) is pretty damn impressive. Instead of talking about the study (because honestly Adel does a terrific job summing it up), I want to emphasize that the people were obese. Why does this matter? Because the leaner you are, the greater the risk for muscle-loss during any form of dieting. The more extreme the diet, the greater the muscle to fat ratio for weight loss will be. That said, I think it’s a great idea to take the 2/3rds overweight population and have them do this for a week. It would actually probably solve a lot of health problems when you think about it.

Picture Perfect

Okay, for my picture perfects I decided that I must confine myself to three pictures per week so that I do not overload you with awesome. I have no idea what they will be about, but I will try and make one have some deeper meaning attached.

 

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